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KMID : 0384119930130010059
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Korean Journal of Clinical Pathology
1993 Volume.13 No. 1 p.59 ~ p.66
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Validation of Dipstick Proteinuria by Urinary Protein/Creatinine Ratio
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Abstract
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Proteinuria, a hallmark of kidney diseases, is typically defined in terms of a 24-hour urinary excretion. Several studies now suggest that the urinary protein/creatinine ratio(P/C ratio) in random urine samples accurately reflects 24-h urine
protein
excretion. The aim of this study is to validate dipstick protein test, which is widely used as a screening test, by urinary P/C ratio in random urine samples. Dipstick protein test and P/C ratio were studied in random urine samples of healthy and
183
in-& our-patients. The 95% range(2.5th to 97.5th percentile) of P/C ratio in healthy adults was 0.015~0.13. Using 0.13 of P/C ratio as the cutoff, trace on the dipstick correlated with adnormal proteinuria in 59.4% of cases, 1+ in 91.5% of cases,
2+ or
more in 100% of cases, whilest 15.6% of negative dipstick values correlated with abnormal proteinuria. Rates of abnormal proteinuria were much higher in the negative dipstick group with the other urinalysis abnormalities or in the trace group
with
positive sulfosalicylic acid test or with repeatedly positive dipstick result after centrifugation, It is concluded that more than 1+ positivity of dipstick protein suggests significant proteinuria and trace result may be significant, in which
cases
sulfosalicylic acid method or repeated dipstick test after centrifugation is recommended. And even if dipstick protein is recommended. And even if dipstick protein is negative, repeated dipstick test and determination of P/C ratio might be
necessary in
some cases.
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KEYWORD
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